UBQLN1 Polyclonal Antibody

• Catalog number
  CAC07954
• Price
  Please ask
• Size
  50 μg

• Other name
  Ubiquilin-1,Protein linking IAP with cytoskeleton 1,PLIC-1,hPLIC-1,UBQLN1,DA41,PLIC1
• Immunogen
  Recombinant Human Ubiquilin-1 protein (1-300AA)
• Verified reactivity
  Human, Mouse, Rat
• Verified applications
  ELISA,WB,IHC,IF. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200,IF:1:50-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q9UMX0
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  UBQLN1  
• Gene symbol
  UBQLN1-AS1, UBQLN1
• Short name
  UBQLN1 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  ubiquilin 1 polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies
• Alternative to gene target
  ubiquilin 1, UBQLN1 and IDBG-73620 and ENSG00000135018 and 29979, protein domain specific binding, nuclei, Ubqln1 and IDBG-157923 and ENSMUSG00000005312 and 56085, BT.92088 and IDBG-636059 and ENSBTAG00000014827 and 282392

Gene info

• Identity
  HGNC:55518
• Gene
  UBQLN1-AS1
• Long gene name
  UBQLN1 antisense RNA 1
• Locus
  9q21.32
• Discovery year
  2021-03-17
• Entrez gene record
  105376114
• RefSeq identity
  • NR_135840
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:12508
• Gene
  UBQLN1
• Long gene name
  ubiquilin 1
• Synonyms
  • DSK2
  • PLIC-1
  • XDRP1
  • DA41
• GenBank acession
  • AF176069
• Locus
  9q21.32
• Discovery year
  2000-02-18
• Entrez gene record
  29979
• Pubmed identfication
  • 9303440
  • 10807547
• RefSeq identity
  • NM_013438
• Classification
  • Ubiquilin family
• VEGA ID
  OTTHUMG00000020104

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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