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ITD 1 for cell activation

ITD 1 for cell activation is available 2 times from Biovision labs

2879-50 | ITD-1 for cell activation size: 50 mg | 717.07 USD

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2879-10 | ITD-1 for cell activation size: 10 mg | 223.52 USD

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Other name 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
Supplied with N/A
Description ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ =  0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
Category Biochemicals
Molecular formula C₂₇H₂₉NO₃
Is it cell-permeable? Yes
Molecular weight 415.52
Storage condition -20°C
Shipping condition gel pack
Purification ≥98% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 1099644-42-4
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance Off-white solid
Reconstitute instructions DMSO (~8 mg/ml) or EtOH (~4 mg/ml with warming)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetITD-1 for activation
Short name ITD-1 for activation
Technique activation
Alternative name ITD-1 to measure cellular activation
Tissue cell
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