OICR-9429

Alternative_name

N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4- ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Description

OICR-9429 is a small-molecule inhibitor of the WDR5-MLL interaction that effectively stops the growth of breast cancer cell lines driven by p53 gene mutation. It also stops the growth of subtype of leukemia cells having specific mutation found in about 9% of the patients with acute myeloid leukemia. WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.
CAS Number

1801787-56-3
Structure Available

Yes
Molecular Formula

C₂₉H₃₂F₃N₅O₃
Molecular Weight

555.59
Cell Permeable

yes
Purity

≥98% by HPLC
Solubilities

DMSO (>25 mg/ml)
Handling

Protect from air and light
Tag Line

An inhibitor of the WDR5-MLL interaction
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

91623360
PubChem CID Link
SMILES

CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC(=CC=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
InChi

InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
InChi Key

DJOVLOYCGXNVPI-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes