S-Adenosyl-L-methionine disulfate tosylate
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Catalog number2077-50
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Price:
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Size50 mg
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Alternative_nameAdoMet SAM disulfate p-toluenesulfonate; SAMe
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DescriptionA methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
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CAS Number97540-22-2
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Structure AvailableYes
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Molecular FormulaC₁₅H₂₂N₆O₅S.C₇H₁₂O₁₁S₂
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Molecular Weight766.8
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Cell PermeableNo
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Purity≥95% by HPLC
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SolubilitiesH₂O (~100 mg/ml)
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HandlingProtect from moisture
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Tag LineA cofactor for catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT)
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Storage Condition-20°C
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Shipping ConditionDry ice
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Shelf Life24 months
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MDL NumberMFCD01674068
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PubChem CID163657
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SMILESCC1=CC=C(C=C1)S(=O)(=O)[O-].C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C2N= CN=C3N)O)O.OS(=O)(=O)[O-].[O-]S(=O)(=O)[O-]
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InChiInChI=1S/C15H22N6O5S.C7H8O3S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11 (23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8, 9)10;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24, 25);2-5H,1H3,(H,8,9,10);2*(H2,1,2,3,4)/p-3/t7-,8+,10+,11+,14+, 27?;;;/m0.../s1
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InChi KeyXDCFCHNAIMYBAZ-XQVUROGGSA-K
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MSDS AvailableYes
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Gene target
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Gene symbolCPT1A, POM121L2, L3MBTL2, CLDN10, RPL32P1, FABP1, COX7A2, NFIA, MAS1L, ANP32E
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Short nameS-Adenosyl-L-methionine disulfate tosylate
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Alternative nameS-Adenosyl-L-methionine disulfate tosylate
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Gene info
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Identity
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Gene
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Long gene namecarnitine palmitoyltransferase 1A
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Synonyms gene
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Synonyms gene name
- carnitine palmitoyltransferase 1A (liver)
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-05-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namePOM121 transmembrane nucleoporin like 2
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Synonyms gene name
- POM121 membrane glycoprotein-like 2 (rat)
- POM121 membrane glycoprotein-like 2
- POM121 transmembrane nucleoporin-like 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-07-20
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameL3MBTL histone methyl-lysine binding protein 2
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Synonyms gene name
- l(3)mbt-like 2 (Drosophila)
- L3MBTL2, polycomb repressive complex 1 subunit
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-04-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MBT domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameclaudin 10
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-01-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Claudins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameribosomal protein L32 pseudogene 1
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Synonyms gene
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Synonyms gene name
- ribosomal protein L32 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2009-03-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid binding protein 1
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Synonyms gene name
- fatty acid binding protein 1, liver
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fatty acid binding protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecytochrome c oxidase subunit 7A2
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Synonyms gene name
- cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mitochondrial complex IV: cytochrome c oxidase subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenuclear factor I A
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Synonyms gene name
- nuclear factor I/A
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-03-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Nuclear factor I family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMAS1 proto-oncogene like, G protein-coupled receptor
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Synonyms gene name
- MAS1 oncogene-like
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-18
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Entrez gene record
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RefSeq identity
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Classification
- G protein-coupled receptors, Class A orphans
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameacidic nuclear phosphoprotein 32 family member E
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Synonyms gene name
- acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-04-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ANP32 acidic nuclear phosphoproteins
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VEGA ID