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anti Antithrombin III Antibody

anti Antithrombin III Antibody is available 2 times from Biovision labs

7013-30T | anti-Antithrombin III Antibody size: Antithrombin III Antibody | 174.28 USD

Catalog number 7013-30T
Supplier Biovision
Price 174.28 USD
Size Antithrombin III Antibody
Formulation of this antibody: 30 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
1. Gene info
Identity 7064
Gene MGST3
Long gene name microsomal glutathione S-transferase 3
Synonyms
  • GST-III
Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
GenBank acession
  • AF026977
Locus 1q24.1
Discovery year 1997-10-16
Entrez gene record 4259
Pubmed identfication
  • 9278457
RefSeq identity
  • NM_004528
Classification
  • Microsomal glutathione S-transferases
Havana BLAST/BLAT OTTHUMG00000034627
2. Gene info
Identity 775
Gene SERPINC1
Long gene name serpin family C member 1
Synonyms gene
  • AT3
Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
  • serpin peptidase inhibitor, clade C (antithrombin), member 1
Synonyms
  • ATIII
  • MGC22579
Synonyms name
  • antithrombin III
  • signal peptide antithrombin part 1
  • coding sequence signal peptide antithrombin part 1
  • antithrombin (aa 375-432)
GenBank acession
  • X68793
Locus 1q25.1
Discovery year 1986-01-01
Entrez gene record 462
Pubmed identfication
  • 3979120
  • 24172014
RefSeq identity
  • NM_000488
Classification
  • Serpin peptidase inhibitors
Havana BLAST/BLAT OTTHUMG00000037276
Locus Specific Databases
  • Antithrombin III mutation database
  • LRG_577
Product images
    #0#.jpegAntithrombin III Antibody

7013-100 | anti-Antithrombin III Antibody size: Antithrombin III Antibody | 400.73 USD

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Target of this antibody: Antithrombin III
Alternative names of antibody target: SERPINC1
Background information: SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. Antithrombin III is found in normal serum at 15 mg per 100 ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: rabbit IgG
Clone: N/A
This antibody reacts with: Human, Mouse, Rat
Immunogene sequence: Human antithrombin III (Cat# 7298)
Concentration of antibody: 0.5 mg/ml
Form of antibody: Liquid
Purification method: Affinity purified rabbit IgG
This antibody has been succesfully tested for use in following methods: Western blot
Recommended usage: Western blot: 1-4 µg
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetAntithrombin III
Short name anti-Antithrombin III Antibody
Technique Antibody, anti
Alternative name antibody to-Antithrombin III (Antibody to)
Alternative technique antibodies
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  • Antithrombin
  • III
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