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Alternative name1
Anti-RABBIT ANTI MOUSE TRIAD3A (N-TERMINAL)
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Alternative name2
RABBIT ANTI Murine TRIAD3A (N-TERMINAL)
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Alternative name3
Lapin ANTI Mus musculus TRIAD3A (N-TERMINAL)
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Alternative name4
TRIAD3A
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Alternative name5
N/A
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Other names
E3 ubiquitin-protein ligase RNF216 isoform A; E3 ubiquitin-protein ligase RNF216; E3 ubiquitin-protein ligase RNF216; E3 ubiquitin ligase; ubcM4-interacting protein 83; triad domain-containing protein 3; ubiquitin-conjugating enzyme 7-interacting protein 1; ring finger protein 216; RING finger protein 216; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1
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Gene name
TRIAD3A
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Gene name synonims
N/A
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Other gene names
Rnf216; Rnf216; UIP83; C86502; TRIAD3; AI647468; AU019462; Ubce7ip1; 2810055G22Rik; F830018F18Rik; Triad3; Ubce7ip1; Uip83; Zin
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Mouse
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Specificity and cross reactivity
TRIAD3A Recognises an epitope within the N-terminal region (NT) of mouse TRIAD3A, a ubiquitously expressed E3 ubiquitin-protein ligase which plays an important role in the innate immune response. _x000D__x000D_Regulation of the level and duration of Toll-like receptor (TLR) activation is vital in controlling a pro-inflammatory response, to prevent harm to the host. Several proteins involved in the regulation of TLR signaling have been described including ST2 and IL-1R-associated kinase M, along with many other adaptor proteins of the MyD88 family, which mediate TLR signal transduction. TRIAD3A, identified as a RING finger member of the E3 ligase family of proteins, binds to the cytoplasmic tail of several TLRs, notably TLR4 and TLR9, resulting in ubiquitination and proteolytic degradation, thereby regulating their expression. TRIAD3A does not appear to regulate the expression of TLR2._x000D_
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
IgG concentration 1.0mg/ml
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested for
Immunohistology - Paraffin (IHC), Western Blot (WB)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus