PJ-34 hydrochloride

• Catalog number
  2319-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride
• Description
  A potent, water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC₅₀ = 20 nM). Inhibits peroxynitrite-induced cell necrosis and displays significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Suppresses cell growth in liver cancer cells.
• CAS Number
  344458-15-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₇N₃O₂.HCl
• Molecular Weight
  331.8
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~30 mg/ml) or H₂O (~ 30 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent poly(ADP-ribose) polymerase (PARP) inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD03452993
• PubChem CID
  16219859
• PubChem CID Link
• SMILES
  CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.O.Cl
• InChi
  InChI=1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
• InChi Key
  YCALIZUKAFUQCH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PJ-34   hydrochloride  
• Gene symbol
  SNORD115-34, IGKV3D-34, IGHV4-34, IGKV3-34, IGLV2-34, IGHV7-34-1, RNU6-34P, RASSF2, PHF11, IL34
• Short name
  PJ-34 hydrochloride
• Alternative name
  PJ-34 hydrochloride

Gene info

• Identity
  HGNC:33053
• Gene
  SNORD115-34
• Long gene name
  small nucleolar RNA, C/D box 115-34
• Synonyms
  • HBII-52-34
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033808
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003349.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5828
• Gene
  IGKV3D-34
• Long gene name
  immunoglobulin kappa variable 3D-34 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 3D-34
  • immunoglobulin kappa variable 3D-34 pseudogene
• GenBank acession
  • X71895
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28871
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151601

Gene info

• Identity
  HGNC:5650
• Gene
  IGHV4-34
• Long gene name
  immunoglobulin heavy variable 4-34
• GenBank acession
  • X92278
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28395
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152074

Gene info

• Identity
  HGNC:5820
• Gene
  IGKV3-34
• Long gene name
  immunoglobulin kappa variable 3-34 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 3-34
  • immunoglobulin kappa variable 3-34 pseudogene
• GenBank acession
  • X71891
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28909
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151693

Gene info

• Identity
  HGNC:5893
• Gene
  IGLV2-34
• Long gene name
  immunoglobulin lambda variable 2-34 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 2-34
  • immunoglobulin lambda variable 2-34 pseudogene
• GenBank acession
  • D87013
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28810
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151174

Gene info

• Identity
  HGNC:5664
• Gene
  IGHV7-34-1
• Long gene name
  immunoglobulin heavy variable 7-34-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 7-34-1
  • immunoglobulin heavy variable 7-34-1 pseudogene
• GenBank acession
  • AB019439
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28382
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152085

Gene info

• Identity
  HGNC:34278
• Gene
  RNU6-34P
• Long gene name
  RNA, U6 small nuclear 34, pseudogene
• Synonyms gene
  • RNU6-34
• Synonyms gene name
  • RNA, U6 small nuclear 34
• Locus
  4q22.3
• Discovery year
  2008-06-10
• Entrez gene record
  100873749
• RefSeq identity
  • NR_046492

Gene info

• Identity
  HGNC:9883
• Gene
  RASSF2
• Long gene name
  Ras association domain family member 2
• Synonyms gene name
  • Ras association (RalGDS/AF-6) domain family member 2
• Synonyms
  • KIAA0168
  • CENP-34
• Synonyms name
  • centromere protein 34
• GenBank acession
  • D79990
• Locus
  20p13
• Discovery year
  2000-08-22
• Entrez gene record
  9770
• Pubmed identfication
  • 8724849
  • 15806169
• RefSeq identity
  • NM_014737
• Classification
  • Ras association domain family
• VEGA ID
  OTTHUMG00000031790

Gene info

• Identity
  HGNC:17024
• Gene
  PHF11
• Long gene name
  PHD finger protein 11
• Synonyms
  • NY-REN-34
  • BCAP
  • IGER
• Synonyms name
  • IgE responsiveness (atopic)
• GenBank acession
  • AB011031
• Locus
  13q14.2
• Discovery year
  2003-05-08
• Entrez gene record
  51131
• Pubmed identfication
  • 10508479
  • 15057823
• RefSeq identity
  • NM_016119
• Classification
  • PHD finger proteins
• VEGA ID
  OTTHUMG00000016916

Gene info

• Identity
  HGNC:28529
• Gene
  IL34
• Long gene name
  interleukin 34
• Synonyms gene
  • C16orf77
• Synonyms gene name
  • chromosome 16 open reading frame 77
• Synonyms
  • MGC34647
  • IL-34
• GenBank acession
  • BC029804
• Locus
  16q22.1
• Discovery year
  2006-08-01
• Entrez gene record
  146433
• Pubmed identfication
  • 18467591
• RefSeq identity
  • NM_152456
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000137581

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