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Alternative_name
MeOSuc-Ala-Ala-Pro-Val-chloromethylketone; MeOSuc-AAPV-CMK
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Description
A potent, irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).
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CAS Number
65144-34-5
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Structure Available
Yes
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Peptide sequence
Yes
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Salt Form
No
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Molecular Formula
C₂₂H₃₅ClN₄O₇
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Molecular Weight
503
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Cell Permeable
No
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Purity
≥98% by TLC
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Solubilities
DMSO
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Handling
Protect from air and mositure
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Tag Line
A potent, irreversible human leukocyte elastase (HLE) inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00077136
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PubChem CID
5486692
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SMILES
CC(C)C(C(=O)CCl)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC
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InChi
InChI=1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22 (33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3, (H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
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InChi Key
PJGDFLJMBAYGGC-XLPNERPQSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
