Filters
Ajax processing
Ajax processing
Ajax processing
Ajax processing
Ajax processing
Ajax processing
Ajax processing
Ajax processing
Ajax processing

Human CellExp ErbB2 HER2 CD340 human recombinant

Human CellExp ErbB2 HER2 CD340 human recombinant is available 4 times from Biovision labs

7397-10 | Human CellExp ErbB2 / HER2 / CD340, human recombinant size: 10 μg | 400.62 USD

Loading

7397-50 | Human CellExp ErbB2 / HER2 / CD340, human recombinant size: 50 μg | 877.83 USD

Loading

7397-10 | Human CellExp™ ErbB2 / HER2 / CD340, human recombinant size: 10 μg | 289.86 USD

Loading

7397-50 | Human CellExp™ ErbB2 / HER2 / CD340, human recombinant size: 50 μg | 821.28 USD

Loading
Target ErbB2
Background Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.
Concentration N/A
Molecular weight This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 72.4 kDa. The predicted N-terminus is Thr 23. DTT-reduced Protein migrates as 90-110 kDa due to glycosylation.
Synonym ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
Other name ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
NCBI gene number 2064
NCBI gene ErbB2
Gene source Human
NCBI number P04626
Recombinant Yes
Source HEK293 cells
Purification ≥95%
Tested applications SDS-PAGE, N/A
Tested activity N/A
Biological activity Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. The ED50 for this effect is typically 5-45 ng/ml in the presence of 0.6 μg/ml goat anti-hErbB2.
Reesults Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. The ED50 for this effect is typically 5-45 ng/ml in the presence of 0.6 μg/ml goat anti-hErbB2.
Binding ability N/A
Unit N/A
Storage condition -20°C
Shipping under Gel Pack
Physical appearance Lyophilized
Physical properties Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
How to reconstitute Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Aa sequence N/A
Before use Centrifuge the vial prior to opening.
Notes For Research Use Only! Not to be used in humans
Synonyms ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
Alternates names ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
Taglines Involved in the signal transduction pathways leading to cell growth and differentiation.
Biomolecule/Target ErbB2
NCBI Gene ID #. 2064
NCBI Gene Symbol ErbB2
Gene Source Human
Accession # P04626
Purity N/A
Activity (Specifications/test method) N/A
Results Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. The ED50 for this effect is typically 5-45 ng/ml in the presence of 0.6 μg/ml goat anti-hErbB2.
Molecular Weight This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 72.4 kDa. The predicted N-terminus is Thr 23. DTT-reduced Protein migrates as 90-110 kDa due to glycosylation.
Storage Temp. -20°C
Shipping Gel Pack
Shelf Life 1 year
Appearance Lyophilized
Physical form description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Technique Recombinant
Alternative technique rec
Alternative to gene target v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), CD340 and HER-2 and HER-2/neu and HER2 and MLN 19 and NEU and NGL and TKR1, ERBB2 and IDBG-46068 and ENSG00000141736 and 2064, transferase activity, nuclei, Erbb2 and IDBG-210591 and ENSMUSG00000062312 and 13866, ERBB2 and IDBG-639410 and ENSBTAG00000021798 and 505709
Similar products
SSB antibody Suppplier: MBS Monoclonals
Price: 742.33 USD
Anti-CCR3 Picoband antibody Suppplier: boster
Price: 506.67 USD
ELISA kit for Human anti cytomegalovirus antibody anti CMV Suppplier: Pariselements
Price: 484.28 USD
BrdU bromodeoxyuridine Suppplier: MBS Monoclonals
Price: 435.97 USD
BMI1 polyclonal antibody Suppplier: Bioworld
Price: 421.83 USD
MLKL 8H7 Mouse Monoclonal Antibody Suppplier: ELK Biotech
Price: 351.13 USD
KPNA4 Peptide Suppplier: Zyagen
Price: 240.37 USD
Indocyanine Green (~90%) Suppplier: trca
Price: 135.50 USD
Duck Lysine ELISA Kit Suppplier: MyBioSource
Price: 5.89 USD
Human RPL21P25 CRISPR Knock Out Cell Line Suppplier: ABM CrispR
Price: 6 858.88 USD
Dynein light chain 1 cytoplasmic dlc 1 Suppplier: MBS Recombinant
Price: 1 575.39 USD
Recombinant Human Anoctamin Suppplier: MyBioSource
Price: 0.00 USD
Pyrimidine-5-boronicacidhemihydrate,97% Suppplier: SFC
Price: 0.00 USD
Hccs 3 UTR Luciferase Stable Cell Line Suppplier: ABM microrna
Price: 0.00 USD
Ac-Lys(Boc)-OH Suppplier: SFC
Price: 0.00 USD
Ask
Ajax processing
Close
Human CellExp ErbB2 HER2 CD340 human recombinant
Filters
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • CellExp
  • ErbB2
  • HER2
  • CD340
Back
Contact us
Ajax processing
Close
Chat with gentaur.com employee