WZ-3146

• Catalog number
  B2206-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide
• Description
  WZ-3146 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.
• CAS Number
  1214265-56-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₅ClN₆O₂
• Molecular Weight
  464.95
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A mutant selective EGFR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44607360
• PubChem CID Link
• SMILES
  CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
• InChi
  InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-2
• InChi Key
  APHGZZPEOCCYNO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  WZ-3146  
• Gene symbol
  MIR3146
• Short name
  WZ-3146
• Alternative name
  WZ-3146

Gene info

• Identity
  HGNC:38368
• Gene
  MIR3146
• Long gene name
  microRNA 3146
• Synonyms
  • hsa-mir-3146
• Locus
  7p21.1
• Discovery year
  2010-04-30
• Entrez gene record
  100422967
• RefSeq identity
  • NR_036101
• Classification
  • MicroRNAs

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