HC Toxin
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Catalog number2728-1000
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PricePlease ask
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Size1 mg
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Alternative_name(6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone; Toxin I (Helminthosporium carbonum)
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DescriptionHC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells
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CAS Number83209-65-8
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₂₁H₃₂N₄O₆
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Molecular Weight436.5
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Cell PermeableYes
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Purity≥95%
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA histone deacetylase (HDAC) inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life36 months
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MDL NumberMFCD00133388
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PubChem CID23724535
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SMILESO=C(C1CO1)CCCCC[C@@H](C(N2[C@]3([H])CCC2)=O)NC([C@@H](C)NC([C@H](C)NC3=O)=O)=O
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InChiInChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1
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InChi KeyGNYCTMYOHGBSBI-KVUCBBCISA-N
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MSDS AvailableYes
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Gene target-
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Gene symbolCLTC, SRRD, AMBP
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Short nameHC
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Alternative nameHC Toxin
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Gene info
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Identity
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Gene
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Long gene nameclathrin heavy chain
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Synonyms gene
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Synonyms gene name
- clathrin, heavy polypeptide (Hc)
- clathrin, heavy chain
- clathrin, heavy polypeptide-like 2
- clathrin, heavy chain (Hc)
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-10-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Clathrin subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSRR1 domain containing
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2007-12-05
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namealpha-1-microglobulin/bikunin precursor
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Lipocalins
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VEGA ID