SNS-314

• Catalog number
  2446-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea mesyalte
• Description
  A potent pan-Aurora kinase inhibitor. Inhibits Aurora kinases A, B, and C with IC₅₀ values of 9 nM, 31 nM and 3 nM, respectively. Displays potent anti-tumor activity.
• CAS Number
  1057249-41-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₅ClN₆OS₂
• Molecular Weight
  430.93
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent pan-Aurora kinase inhibitor.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  24995524
• PubChem CID Link
• SMILES
  C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4
• InChi
  InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
• InChi Key
  FAYAUAZLLLJJGH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SNS-314  
• Gene symbol
  SCN10A, SCN11A
• Short name
  SNS-314
• Alternative name
  SNS-314

Gene info

• Identity
  HGNC:10582
• Gene
  SCN10A
• Long gene name
  sodium voltage-gated channel alpha subunit 10
• Synonyms gene name
  • sodium channel, voltage-gated, type X, alpha polypeptide
  • sodium channel, voltage-gated, type X, alpha subunit
  • sodium channel, voltage gated, type X alpha subunit
• Synonyms
  • Nav1.8
  • hPN3
  • SNS
  • PN3
• Synonyms name
  • sensory neuron sodium channel
  • peripheral nerve sodium channel 3
• GenBank acession
  • AF117907
• Locus
  3p22.2
• Discovery year
  1996-04-12
• Entrez gene record
  6336
• Pubmed identfication
  • 9839820
  • 10198179
  • 16382098
• RefSeq identity
  • NM_006514
• Classification
  • Sodium voltage-gated channel alpha subunits
• VEGA ID
  OTTHUMG00000048245

Gene info

• Identity
  HGNC:10583
• Gene
  SCN11A
• Long gene name
  sodium voltage-gated channel alpha subunit 11
• Synonyms gene
  • SCN12A
• Synonyms gene name
  • sodium channel, voltage-gated, type XI, alpha polypeptide
  • sodium channel, voltage-gated, type XII, alpha
  • sodium channel, voltage-gated, type XI, alpha subunit
  • sodium channel, voltage gated, type XI alpha subunit
• Synonyms
  • Nav1.9
  • NaN
  • SNS-2
• GenBank acession
  • AF126739
• Locus
  3p22.2
• Discovery year
  1998-11-06
• Entrez gene record
  11280
• Pubmed identfication
  • 10444332
  • 16382098
• RefSeq identity
  • NM_014139
• Classification
  • Sodium voltage-gated channel alpha subunits
• VEGA ID
  OTTHUMG00000048246

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