-
Alternative_name
N-(2-fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidine-1-carboxamido)pyridin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; E7050; E-7050; E 7050
-
Description
Golvatinib ( E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.
-
CAS Number
928037-13-2
-
Structure Available
Yes
-
Salt Form
No
-
Molecular Formula
C₃₃H₃₇F₂N₇O₄
-
Molecular Weight
633.69
-
Cell Permeable
Yes
-
Purity
≥98% by HPLC
-
Solubilities
DMSO
-
Handling
Protect from air and light
-
Tag Line
A potent c-Met and VEGFR-2 kinase inhibitor
-
Storage Condition
-20°C
-
Shipping Condition
gel pack
-
Shelf Life
36 months
-
PubChem CID
16118392
-
-
SMILES
CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
-
InChi
InChI=1S/C33H37F2N7O4/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45)
-
InChi Key
UQRCJCNVNUFYDX-UHFFFAOYSA-N
-
-
MSDS Available
Yes
