PU-H71

• Catalog number
  9649-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
• Description
  PU-H71 is a potent Heat Shock Protein 90 (Hsp90) inhibitor (IC₅₀ = 50 nM). Also inhibits cell growth in a range of breast cancer cell lines (IC₅₀ values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
• CAS Number
  873436-91-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₂₁IN₆O₂S
• Molecular Weight
  512.37
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent Heat Shock Protein 90 (Hsp90) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9549213
• PubChem CID Link
• SMILES
  CC(C)NCCCN1C2=C(C(=NC=N2)N)N=C1SC3=C(C=C4C(=C3)OCO4)I
• InChi
  InChI=1S/C18H21IN6O2S/c1-10(2)21-4-3-5-25-17-15(16(20)22-8-23-17)24-18(25)28-14-7-13-12(6-11(14)19)26-9-27-13/h6-8,10,21H,3-5,9H2,1-2H3,(H2,20,22,23)
• InChi Key
  SUPVGFZUWFMATN-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PU-H71  
• Gene symbol
  SPI1
• Short name
  PU-H71
• Alternative name
  PU-H71

Gene info

• Identity
  HGNC:11241
• Gene
  SPI1
• Long gene name
  Spi-1 proto-oncogene
• Synonyms gene name
  • spleen focus forming virus (SFFV) proviral integration oncogene
• Synonyms
  • PU.1
  • SPI-A
  • OF
  • SFPI1
  • SPI-1
• Synonyms name
  • hematopoietic transcription factor PU.1
  • 31 kDa transforming protein
• GenBank acession
  • X52056
• Locus
  11p11.2
• Discovery year
  1988-07-04
• Entrez gene record
  6688
• Pubmed identfication
  • 1693183
• RefSeq identity
  • NM_003120
• Classification
  • ETS transcription factor family
• VEGA ID
  OTTHUMG00000150150

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