PLD6 Polyclonal Antibody
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Catalog numberCAC07666
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PricePlease ask
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Size50 μg
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Other nameMitochondrial cardiolipin hydrolase,Choline phosphatase 6,Mitochondrial phospholipase1,PLD6
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ImmunogenRecombinant human Mitochondrial cardiolipin hydrolase protein (1-252AA)
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Verified reactivityHuman, Mouse
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Verified applicationsELISA,WB,IHC,IF. Recommended dilution:WB:1:2000-1:5000,IHC:1:20-1:200,IF:1:50-1:200
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Raised inRabbit
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ClonalityPolyclonal
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Protein numberQ8N2A8
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Gene numberPlease refer to GenBank
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NCBI numberPlease refer to NCBI
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PurityProtein G purified, >95%
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Storage recommendationAliquot and store at -20°C. Minimize freezing and thawing.
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Use before1 year
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Shipping requirementsBlue ice
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Estimated production time3-7 business days
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Supplementary informationEndonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).
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NotesFor research use only. Not for diagnostic procedures.
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PropertiesIf you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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French translationanticorps
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Gene target
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Gene symbolPLD6
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Short namePLD6 Polyclonal Antibody
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TechniquePolyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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LabelUnconjugated
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Alternative namePLD6 polyclonal (antibody to-)
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Alternative techniquepolyclonals, antibodies
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Gene info
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Identity
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Gene
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Long gene namephospholipase D family member 6
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Synonyms gene name
- phospholipase D family, member 6
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2008-08-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Phospholipases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data