PD-1/PD-L1 Inhibitor 2

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Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

PD-1/PD-L1 Inhibitor
Gene symbol

PDCD1, CD274, ENPP2, ENPP3, PDCD1LG2, VSIR, SNCA, SPATA2, MTA2, MICALL1
Short name

PD-1/PD-L1 Inhibitor 2
Alternative name

PD-1/PD-L1 suppressor 2

Identity

HGNC:3358
Gene

ENPP3
Long gene name

ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms gene
- PDNP3
Synonyms
- PD-IBETA
- gp130RB13-6
- B10
- CD203c
GenBank acession
- AF005632
Locus

6q23.2
Discovery year

1995-08-10
Entrez gene record

5169
Pubmed identfication
- 9344668
Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
- CD molecules
VEGA ID

OTTHUMG00000016292

Identity

HGNC:18731
Gene

PDCD1LG2
Long gene name

programmed cell death 1 ligand 2
Synonyms
- PD-L2
- Btdc
- PDL2
- bA574F11.2
- CD273
- B7-DC
Synonyms name
- B7 dendritic cell molecule
GenBank acession
- AF344424
Locus

9p24.1
Discovery year

2003-11-14
Entrez gene record

80380
Pubmed identfication
- 11224527
RefSeq identity
- NM_025239
Classification
- B7 family
- CD molecules
- Immunoglobulin like domain containing
- Receptor ligands
VEGA ID

OTTHUMG00000019504

Identity

HGNC:11138
Gene

SNCA
Long gene name

synuclein alpha
Synonyms gene
- PARK1
- PARK4
Synonyms gene name
- Parkinson disease (autosomal dominant, Lewy body) 4
- synuclein, alpha (non A4 component of amyloid precursor)
Synonyms
- NACP
- PD1
Synonyms name
GenBank acession
- L08850
Locus

4q22.1
Discovery year

1995-01-24
Entrez gene record

6622
Pubmed identfication
- 8248242
- 14593171
VEGA ID

OTTHUMG00000130948
Locus Specific Databases
- Global Variome shared LOVD

Identity

HGNC:7411
Gene

MTA2
Long gene name

metastasis associated 1 family member 2
Synonyms gene
- MTA1L1
Synonyms gene name
- metastasis associated gene family, member 2
Synonyms
- MTA1-L1
GenBank acession
- AB016591
Locus

11q12.3
Discovery year

1999-05-17
Entrez gene record

9219
Pubmed identfication
- 9929979
RefSeq identity
- NM_004739
Classification
- GATA zinc finger domain containing
- NuRD complex subunits
- Myb/SANT domain containing
VEGA ID

OTTHUMG00000167684