Oxythiamine Chloride Hydrochloride
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Catalog number
B1046-1000
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Price
Please ask
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Size
1 g
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Alternative_name
5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
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Description
Oxythiamine is a thiamine antagonist that acts as a transketolase inhibitor. As transketolase is a crucial enzyme of the pentose phosphate pathway, inhibition of this enzyme causes suppression of the pentose phosphate pathway and thus deprives cells of the metabolic intermediate (glyceraldehyde-3-phosphate) for ATP generation and of the substrates (NADPH, ribose-phosphate) for macromolecule synthesis. This metabolic inhibition seems to be responsible, at least in part, for the significant anticancer activity observed in vitro and in vivo.
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CAS Number
614-05-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₂H₁₆ClN₃O₂S.HCl
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Molecular Weight
338.25
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Cell Permeable
Yes
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Purity
≥95% by HPLC
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Solubilities
DMSO (>50 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A thiamine antagonist that acts as a transketolase inhibitor.
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00050656
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PubChem CID
56845140
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SMILES
CC1=C(SC=[N+]1CC2=CN=C(N=C2N=O)C)CCO.Cl.[Cl-]
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InChi
InChI=1S/C12H15N4O2S.2ClH/c1-8-11(3-4-17)19-7-16(8)6-10-5-13-9(2)14-12(10)15-18;;/h5,7,17H,3-4,6H2,1-2H3;2*1H/q+1;;/p-1
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InChi Key
BNURZUBKXXZBQE-UHFFFAOYSA-M
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MSDS Available
Yes
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