JARID2 polyclonal antibody
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Catalog number6856-50
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Price:
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Size50 μl
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Antibody TargetJARID2
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Target Alternative NameJMJ
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Antibody TypePolyclonal
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Species ReactivitiesHuman.
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Immunogen SequencePolyclonal antibody raised in rabbit against human JARID2 (jumonji, AT rich interactive domain 2) using two KLH conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively.
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AccessionQ92833
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Gene Id3720
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AppearanceColorless liquid
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FormLiquid
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FormulationIn PBS with 0.05% (W/V) sodium azide.
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PurificationWhole Anti-Sera
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ApplicationELISA.
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Positive ControlELISA: Peptides.
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Application And UsagesELISA: 1:500.
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DescriptionJARID2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. JARID2 acts by recruiting histone methyltransferase complexes (PRC2) to their target genes and modulating the histone methyltransferase activity. It does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of H3K27me3 by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating H3K9 methylation by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedNot Verified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedVerified
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ChIP VerifiedNot Verified
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Dot Blot VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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French translationanticorps
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Gene target
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Gene symbolJARID2-AS1, JARID2, JARID2-DT
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Short nameJARID2 polyclonal antibody
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TechniquePolyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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IsotypeRabbit IgG
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Alternative namejumonji, AT rich interactive domain 2 polyclonal (antibody to-)
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Alternative techniquepolyclonals, antibodies
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Alternative to gene targetjumonji, AT rich interactive domain 2, JMJ, JARID2 and IDBG-62820 and ENSG00000008083 and 3720, protein binding, nuclei, Jarid2 and IDBG-147776 and ENSMUSG00000038518 and 16468, JARID2 and IDBG-636025 and ENSBTAG00000012938 and 528253
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Gene info
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Identity
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Gene
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Long gene nameJARID2 antisense RNA 1
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Synonyms gene name
- JARID2 antisense RNA 1 (non-protein coding)
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GenBank acession
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Locus
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Discovery year2011-12-05
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Entrez gene record
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namejumonji and AT-rich interaction domain containing 2
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Synonyms gene
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Synonyms gene name
- jumonji (mouse) homolog
- Jumonji, AT rich interactive domain 2
- jumonji, AT rich interactive domain 2
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GenBank acession
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Locus
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Discovery year1997-09-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Iron (II) and 2-oxoglutarate dependent oxygenases
- AT-rich interaction domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameJARID2 divergent transcript
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Locus
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Discovery year2020-09-16
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Classification
- Divergent transcripts
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data