LY-2940680

Alternative_name

4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide; LY2940680; Taladegib
Description

LY-2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling pathway. Displays anticancer properties.
CAS Number

1258861-20-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₆H₂₄F₄N₆O
Molecular Weight

512.5
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent Hedgehog (Hh) signaling pathway inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

49848070
PubChem CID Link
SMILES

CN1C(=CC=N1)C2=NN=C(C3=CC=CC=C32)N4CCC(CC4)N(C)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F
InChi

InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3
InChi Key

SZBGQDXLNMELTB-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes