CNOT2(Ser101) Antibody, ALEXA FLUOR 647

• Catalog number
  bs-9384R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  CNOT2(Ser101) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-CNOT2 Ser101 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CNOT2 Ser101
• Specificity
  This is a highly specific antibody against CNOT2 Ser101.
• Modification
  Phosphorylation
• Modification Site
  Ser101
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human CNOT2 around the phosphorylation site of Ser101
• Gene ID Number
  4848
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  CNOT2 (CCR4-NOT transcription complex subunit 2) is a ubiquitous protein encoded by the human gene CNOT2. CNOT2 belongs to the CNOT2/3/5 family and is part of the CCR4-NOT complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT2) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. Increased expression of the CNOT2 subunit acts to strongly repress transcription by RNA polymerase II. This repressive effect is mediated by a conserved NOT-Box, which is located at the C-terminus of CNOT2 proteins. Repression by the NOT-Box is sensitive to treatment with the histone deacetylase (HDAC) inhibitor trichostatin A.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  CNOT2 phospho S101; p-CNOT2Ser101; CCR4 associated factor 2; CCR4 NOT transcription complex subunit 2; CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CDC36; CNOT2; CNOT2_HUMAN; HSPC131; MSTP046; Negative regulator of transcription 2; NOT2 negative regulator of transcription 2 yeast homolog; NOT2; NOT2H.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-CNOT2 Ser101 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  CNOT2   Ser101  
• Gene symbol
  PRANCR, CNOT2
• Short name
  Anti-CNOT2 Ser101
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  CNOT2(Ser101) Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:51126
• Gene
  PRANCR
• Long gene name
  progenitor renewal associated non-coding RNA
• Synonyms gene
  • LINC01481
  • CNOT2-DT
• Synonyms gene name
  • long intergenic non-protein coding RNA 1481
  • CNOT2 divergent transcript
• Locus
  12q15
• Discovery year
  2014-07-30
• Entrez gene record
  101928062
• Pubmed identfication
  • 31804951
• RefSeq identity
  • NR_120460
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000169448

Gene info

• Identity
  HGNC:7878
• Gene
  CNOT2
• Long gene name
  CCR4-NOT transcription complex subunit 2
• Synonyms gene
  • NOT2
• Synonyms gene name
  • CCR4-NOT transcription complex, subunit 2
• Synonyms
  • CDC36
  • NOT2H
• GenBank acession
  • AF180473
• Locus
  12q15
• Discovery year
  1996-07-19
• Entrez gene record
  4848
• Pubmed identfication
  • 10637334
• Classification
  • CCR4-NOT transcription complex
• VEGA ID
  OTTHUMG00000169481

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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