AZ-3146

Alternative_name

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Description

AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor (IC₅₀ = 35 nM). Shows selectivity over 46 other kinases including aurora kinase B and Cdk1. AZ 3146 overrides spindle assembly checkpoint and also interferes with chromosome alignment. It has shown to inhibit the recruitment of Mad1, 2 and centromere protein E (CENP-E) to kinetochores.
CAS Number

1124329-14-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₄H₃₂N₆O₃
Molecular Weight

452.55
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO(>10 mg/ml))
Handling

Protect from air and light
Tag Line

potent and selective Mps1 (monopolar spindle 1) kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD18384959
PubChem CID

56973724
PubChem CID Link
SMILES

CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
InChi

1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChi Key

YUKWVHPTFRQHMF-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes