anti- MEK1/2 antibody

• Catalog number
  FNab05113
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
• Immunogen
  mitogen-activated protein kinase kinase 2
• Synonyms
  ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, MAP2K2, MAPK/ERK kinase 2, MAPKK 2, MAPKK2, MEK 2, MEK2, MKK2, PRKMK2
• Calculated MW
  53 kDa
• Uniprot ID
  P36507
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, IHC, WB
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
• Image4
  HL-60 cells were subjected to SDS PAGE followed by western blot with FNab05113(MAP2K2 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MEK1/2  
• Gene symbol
  MAP2K1
• Short name
  anti- MEK1/2 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- MEK1/2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6840
• Gene
  MAP2K1
• Long gene name
  mitogen-activated protein kinase kinase 1
• Synonyms gene
  • PRKMK1
• Synonyms
  • MEK1
  • MAPKK1
• GenBank acession
  • L11284
• Locus
  15q22.31
• Discovery year
  1993-11-05
• Entrez gene record
  5604
• Pubmed identfication
  • 9465908
  • 8388392
• Classification
  • Mitogen-activated protein kinase kinases
• VEGA ID
  OTTHUMG00000133196
• Locus Specific Databases
  • The Globin Gene Server
  • LRG_725

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products