CAPON Antibody, ALEXA FLUOR 594
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Catalog numberbs-11987R-A594
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Price:
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Size100ul
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Long nameCAPON Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known asAnti-CAPON PAb ALEXA FLUOR 594
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 594
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenCAPON
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SpecificityThis is a highly specific antibody against CAPON.
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CAPON
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenCAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission590nm/617nm
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SynonymsNOS1AP; C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON; C terminal PDZ domain ligand of neuronal nitric oxide synthase; C terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; CAPON; CAPON_HUMAN; Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain; MGC138500; Nitric oxide synthase 1 neuronal adaptor protein; Nitric oxide synthase 1 adaptor protein.
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PropertiesFor facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR® 594
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ConjugatedAlexa conjugate 1
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French translationanticorps
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Gene target
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Gene symbolNOS1AP
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Short nameAnti-CAPON
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 594
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Alternative nameCAPON Polyclonal Antibody, ALEXA FLUOR 594
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namenitric oxide synthase 1 adaptor protein
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Synonyms gene name
- nitric oxide synthase 1 (neuronal) adaptor protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-06-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data