NEFL shRNA Plasmid (Rat)

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Kit

Plasmid mini made and maxi DNA purification kits can be silica gel or anion exchange, endotoxin free and are used to produce pure plasmids that are small DNA molecules within a cell separated from chromosomal DNA and can replicate independently. They are most commonly found in bacteria as small circular, double-stranded DNA molecules; however, plasmids are sometimes present in archaea and eukaryotic organisms. In nature, plasmids often carry genes that may benefit the survival of the organism, for example antibiotic resistance. While the chromosomes are big and contain all the essential information for living, plasmids usually are very small and contain only additional information. Artificial plasmids are widely used as vectors in molecular cloning, serving to drive the replication of recombinant DNA sequences within host organisms.
About

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name

Rattus norvegicus

Gene target

NEFL shRNA
Gene symbol

NEFL
Short name

NEFL shRNA Plasmid ( )
Technique

plasmid, plasmids in 1
Host

Rat
Species

Rat, Rats
Alternative name

neurofilament, light polypeptide short hairpin RNA Plasmid (Rat)
Alternative technique

plasmids
Alternative to gene target

neurofilament, light polypeptide, CMT1F and CMT2E and NF-L and NF68 and NFL and PPP1R110, NEFL and IDBG-777808 and ENSG00000277586 and 4747, protein binding, Cytoplasm, Nefl and IDBG-176493 and ENSMUSG00000022055 and 18039, NEFL and IDBG-635366 and ENSBTAG00000021949 and 281348

Identity

HGNC:7739
Gene

NEFL
Long gene name

neurofilament light chain
Synonyms gene name
- neurofilament, light polypeptide 68kDa
- neurofilament, light polypeptide
- neurofilament light
Synonyms
- NFL
- CMT1F
- CMT2E
- NF68
- PPP1R110
Synonyms name
- protein phosphatase 1, regulatory subunit 110
Locus

8p21.2
Discovery year

2001-06-22
Entrez gene record

4747
Pubmed identfication
- 17620486
- 3145240
RefSeq identity
- NM_006158
Classification
- Intermediate filaments Type IV
- Protein phosphatase 1 regulatory subunits
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000134284
Locus Specific Databases
- Inherited Peripheral Neuropathies Mutation Database
- LRG_259