GW-5074

• Catalog number
  2412-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one
• Description
  Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling.
• CAS Number
  220904-83-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₈Br₂INO₂
• Molecular Weight
  520.95
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~50 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A c-RAF1 kinase inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD03453076
• PubChem CID
  5924208
• PubChem CID Link
• SMILES
  C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
• InChi
  InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
• InChi Key
  LMXYVLFTZRPNRV-KMKOMSMNSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GW-5074  
• Short name
  GW-5074
• Alternative name
  GW-5074

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