VX-809

• Catalog number
  2857-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid; Lumacaftor
• Description
  VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and efficaciously restores function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains.
• CAS Number
  936727-05-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₁₈F₂N₂O₅
• Molecular Weight
  452.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>90 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A novel CFTR corrector
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  16678941
• PubChem CID Link
• SMILES
  CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
• InChi
  InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
• InChi Key
  UFSKUSARDNFIRC-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  VX-809  
• Short name
  VX-809
• Alternative name
  VX-809

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