LDK-378

Alternative_name

5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine; Ceritinib
Description

LDK-378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 200 pM). It displays weaker inhibition against IGF-1R, InsR, and STK22D (IC50s = 8, 7, and 23 nM, respectively), and is minimally effective against a panel of other kinases.
CAS Number

1032900-25-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₈H₃₆ClN₅O₃S
Molecular Weight

558.14
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>10 mg/ml)
Handling

Protect from air and light
Tag Line

A highly potent anaplastic lymphoma kinase (ALK) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

57379345
PubChem CID Link
SMILES

CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
InChi

InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
InChi Key

VERWOWGGCGHDQE-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes