CPI-0610

Alternative_name

(S)-2-(6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
Description

CPI-0610 is a potent, selective BET (bromodomain and extra terminal family of proteins) inhibitor and inhibits BRD4-BD1 with IC₅₀ of 39 nM. It potentially demonstrates anti-neoplastic activity by binding acetylated lysine recognition motifs on the bromodomain of BET proteins, thus preventing the interaction of BET proteins and acetylated histone peptides.
CAS Number

1380087-89-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₆ClN₃O₂
Molecular Weight

365.82
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO(>3 mg/ml)
Handling

Protect from air and light
Tag Line

A potent, and selective BET (bromodomain and extra terminal family of proteins) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

76534645
PubChem CID Link
SMILES

CC1=NOC2=C1C3=CC=CC=C3C(=NC2CC(=O)N)C4=CC=C(C=C4)Cl
InChi

InChI=1S/C20H16ClN3O2/c1-11-18-14-4-2-3-5-15(14)19(12-6-8-13(21)9-7-12)23-16(10-17(22)25)20(18)26-24-11/h2-9,16H,10H2,1H3,(H2,22,25)
InChi Key

GCWIQUVXWZWCLE-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes