Apigenin

• Catalog number
  2508-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Chamomile; Flavone; NSC 83244; Versulin
• Description
  A naturally occurring plant flavone that displays remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. It selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC₅₀ value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI 231 cells. At 5 µM, it is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.
• CAS Number
  520-36-5
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₀O₅
• Molecular Weight
  270.2
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A casein kinase II (CKII) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00006831
• PubChem CID
  5280443
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
• InChi
  InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChi Key
  KZNIFHPLKGYRTM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Apigenin  
• Short name
  Apigenin
• Alternative name
  Apigenin

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