anti- PTEN antibody

• Catalog number
  FNab09821
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
• Immunogen
  phosphatase and tensin homolog
• Synonyms
  MMAC1, TEP1
• Calculated MW
  55 kDa
• Uniprot ID
  P60484
• Specificity
  Human, Mouse, Rat, Monkey
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
• Image1
  Immunohistochemistry of paraffin-embedded human breast hyperplasia tissue slide using FNab09821( PTEN Antibody) at dilution of 1:600
• Image4
  fetal human brain tissue were subjected to SDS PAGE followed by western blot with FNab09821( PTEN Antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PTEN  
• Gene symbol
  PTEN, PTENP1
• Short name
  anti- PTEN antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- phosphatase and tensin homolog (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  phosphatase and tensin homolog, 10q23del and BZS and CWS1 and DEC and GLM2 and MHAM and MMAC1 and PTEN1 and TEP1, PTEN and IDBG-81409 and ENSG00000171862 and 5728, phosphatidylinositol-3, nuclei, Pten and IDBG-158878 and ENSMUSG00000013663 and 19211, PTEN and IDBG-637256 and ENSBTAG00000009498 and 540786

Gene info

• Identity
  HGNC:9588
• Gene
  PTEN
• Long gene name
  phosphatase and tensin homolog
• Synonyms gene
  • BZS
  • MHAM
• Synonyms
  • MMAC1
  • TEP1
  • PTEN1
• Synonyms name
  • mutated in multiple advanced cancers 1
• GenBank acession
  • U92436
• Locus
  10q23.31
• Discovery year
  1997-04-21
• Entrez gene record
  5728
• Pubmed identfication
  • 9090379
• RefSeq identity
  • NM_000314
• Classification
  • PTEN protein phosphatases
  • C2 tensin-type domain containing
  • Phosphoinositide phosphatases
• VEGA ID
  OTTHUMG00000018688
• Locus Specific Databases
  • LRG_311

Gene info

• Identity
  HGNC:9589
• Gene
  PTENP1
• Long gene name
  phosphatase and tensin homolog pseudogene 1
• Synonyms gene name
  • phosphatase and tensin homolog pseudogene 1 (functional)
• Synonyms
  • PTEN2
  • psiPTEN
  • PTH2
  • PTEN-rs
  • PTENpg1
• GenBank acession
  • AF023139
  • BC038293
  • BY797336
• Locus
  9p13.3
• Discovery year
  1999-09-09
• Entrez gene record
  11191
• Pubmed identfication
  • 9393738
  • 9620558
  • 20577206
• RefSeq identity
  • NR_023917
• VEGA ID
  OTTHUMG00000000410

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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