APY29

• Catalog number
  2591-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
• Description
  APY29 is a highly potent and selective allosteric modulator of IRE1α. Under endoplasmic reticulum (ER) stress, unfolded proteins accumulate in the ER to activate the ER transmembrane kinase/endoribonuclease (RNase)—IRE1α. IRE1α oligomerizes, autophosphorylates, and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). APY29 Inhibits IRE1α autophosphorylation (IC₅₀ = 280 nM) and activates IRE1αRNase activity. As dysregulation of the UPR has been implicated in a variety of cell degenerative and neoplastic disorders, small molecule modulators of IRE1α should be very useful in understanding UPR’s role in pathophysiology and to develop drugs for ER stress-related diseases.
• CAS Number
  1216665-49-4
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₆N₈
• Molecular Weight
  332.36
• Cell Permeable
  yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A highly potent and selective allosteric modulator of IRE1α
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• SMILES
  C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=NNC(C5CC5)=C4)=N1
• InChi
  InChI=1S/C17H16N8/c1-2-10(1)13-8-16(25-24-13)22-15-5-6-18-17(23-15)21-11-3-4-12-14(7-11)20-9-19-12/h3-10H,1-2H2,(H,19,20)(H3,18,21,22,23,24,25)
• InChi Key
  WJNBSTLIALIIEW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  APY29  
• Short name
  APY29
• Alternative name
  APY29

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