LY-3200882

Alternative_name

4-[[4-[[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-α,α-dimethyl-2-pyridinemethanol
Description

LY-3200882 is a potent and ATP-competitive inhibitor of TGF-β receptor type 1 (TGF-βRI). It inhibits TGF-β-induced SMAD phosphorylation in vitro and in vivo and exhibits antitumor activity in the 4T1-LP triple negative breast cancer orthotopic tumor model.
CAS Number

1898283-02-7
Structure Available

Yes
Molecular Formula

C₂₄H₂₉N₅O₃
Molecular Weight

435.53
Cell Permeable

1
Purity

≥98% by HPLC
Solubilities

>50 mg/ml (DMSO) in 0
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A TGF-β receptor type 1 (TGF-βRI) inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

121249291
PubChem CID Link
SMILES

CC(C)(C1=NC=CC(=C1)NC2=NC=CC(=C2)OC3=CN(N=C3C4CCOCC4)C5CC5)O
InChi

InChI=1S/C24H29N5O3/c1-24(2,30)21-13-17(5-9-25-21)27-22-14-19(6-10-26-22)32-20-15-29(18-3-4-18)28-23(20)16-7-11-31-12-8-16/h5-6,9-10,13-16,18,30H,3-4,7-8,11-12H2,1-2H3,(H,25,26,27)
InChi Key

PNPFMWIDAKQFPY-UHFFFAOYSA-N
Data Sheet Link