Miransertib

• Catalog number
  B1931-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine; ARQ-092
• Description
  Miransertib is an allosteric, pan-Akt inhibitor (IC₅₀s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). It is selective for Akt isoforms over a panel of 303 other kinases. It binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway.
• CAS Number
  1313881-70-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₄N₆
• Molecular Weight
  432.53
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An allosteric, pan-Akt inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  53262401
• PubChem CID Link
• SMILES
  C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
• InChi
  InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
• InChi Key
  HNFMVVHMKGFCMB-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Miransertib  
• Short name
  Miransertib
• Alternative name
  Miransertib

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