CASP6, CT (Caspase-6, CASP-6, Apoptotic Protease Mch-2, MCH2)

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Description

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

Gene target

CASP6 Caspase-6 CASP-6 Apoptotic Protease Mch-2 MCH2
Gene symbol

CASP6, CRTAP, MCHR2, CASP8, CYTIP, CUX1, MIR1302-6, PIRC28, PIRC24, PIRC26
Short name

CASP6, CT (Caspase-6, CASP-6, Apoptotic Protease Mch-2, MCH2)
Alternative name

caspase 6, apoptosis-related cysteine peptidase, CT (caspase-6, caspase-6, Apoptotic Protease Mch-2, MCH2)
Alternative to gene target

caspase 6, apoptosis-related cysteine peptidase, MCH2, CASP6 and IDBG-33873 and ENSG00000138794 and 839, identical protein binding, nuclei, Casp6 and IDBG-193830 and ENSMUSG00000027997 and 12368, BT.48879 and IDBG-640213 and ENSBTAG00000012537 and 538409

Identity

HGNC:1507
Gene

CASP6
Long gene name

caspase 6
Synonyms gene name
- caspase 6, apoptosis-related cysteine protease
- caspase 6, apoptosis-related cysteine peptidase
Synonyms
- MCH2
GenBank acession
- U20536
Locus

4q25
Discovery year

1996-07-22
Entrez gene record

839
Pubmed identfication
- 8780721
- 7796396
RefSeq identity
- NM_001226
Classification
- Caspases
VEGA ID

OTTHUMG00000131914

Identity

HGNC:2379
Gene

CRTAP
Long gene name

cartilage associated protein
Synonyms
- CASP
- LEPREL3
- P3H5
Synonyms name
- leprecan-like 3
- prolyl 3-hydroxylase family member 5 (non-enzymatic)
GenBank acession
- AJ006470
Locus

3p22.3
Discovery year

1999-10-19
Entrez gene record

10491
Pubmed identfication
- 9217321
- 10429950
Classification
- Prolyl 3-hydroxylase family
VEGA ID

OTTHUMG00000130746
Locus Specific Databases
- Osteogenesis Imperfecta Variant Database
- LRG_4

Identity

HGNC:20867
Gene

MCHR2
Long gene name

melanin concentrating hormone receptor 2
Synonyms gene
- GPR145
Synonyms gene name
- G protein-coupled receptor 145
- melanin-concentrating hormone receptor 2
Synonyms
- SLT
- MCH2
- MCH2R
GenBank acession
- AF347063
Locus

6q16.2
Discovery year

2003-05-13
Entrez gene record

84539
Pubmed identfication
- 11355873
- 11274220
RefSeq identity
- NM_032503
Classification
- Melanin concentrating hormone receptors
VEGA ID

OTTHUMG00000015270

Identity

HGNC:1509
Gene

CASP8
Long gene name

caspase 8
Synonyms gene name
- caspase 8, apoptosis-related cysteine protease
- caspase 8, apoptosis-related cysteine peptidase
Synonyms
- MCH5
- MACH
- FLICE
- Casp-8
GenBank acession
- U60520
Locus

2q33.1
Discovery year

1996-11-11
Entrez gene record

841
Pubmed identfication
- 8681376
- 8681377
RefSeq identity
- NM_001228
Classification
- Caspases
- Death effector domain containing
- Death inducing signaling complex
- Ripoptosome
VEGA ID

OTTHUMG00000132821
Locus Specific Databases
- CASP8base: Mutation registry for Caspase 8 deficiency
- LRG_34

Identity

HGNC:9506
Gene

CYTIP
Long gene name

cytohesin 1 interacting protein
Synonyms gene
- PSCDBP
Synonyms gene name
- pleckstrin homology, Sec7 and coiled-coil domains, binding protein
Synonyms
- B3-1
- HE
- CYBR
- CASP
- CYTHIP
Synonyms name
- cytohesin binding protein HE
- cytohesin binder and regulator
GenBank acession
- L06633
Locus

2q24.1
Discovery year

1999-07-19
Entrez gene record

9595
Pubmed identfication
- 18926288
- 10343115
- 11867758
- 20530790
- 21562043
RefSeq identity
- NM_004288
Classification
- PDZ domain containing
VEGA ID

OTTHUMG00000154551

Identity

HGNC:2557
Gene

CUX1
Long gene name

cut like homeobox 1
Synonyms gene
- CUTL1
Synonyms gene name
- cut (Drosophila)-like 1 (CCAAT displacement protein)
- cut-like 1, CCAAT displacement protein (Drosophila)
- cut-like homeobox 1
Synonyms
- CDP
- CDP1
- CUX
- CUT
- Clox
- CDP/Cut
- CDP/Cux
- Cux/CDP
- CASP
- GOLIM6
Synonyms name
- golgi integral membrane protein 6
- CUX1 gene Alternatively Spliced Product
GenBank acession
- M74099
Locus

7q22.1
Discovery year

1992-12-13
Entrez gene record

1523
Pubmed identfication
- 8468066
- 9799793
- 15004235
RefSeq identity
- NM_001913
Classification
- Golgins
- CUT class homeoboxes and pseudogenes
VEGA ID

OTTHUMG00000157129
Locus Specific Databases
- LRG_1123

Name

Models, Chemical
Concept

Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Tree numbers
- E05.599.495