Anti - CD68CD68 (MACROSIALIN, DKFZp686M18236, Macrophage antigen, SCARD1, Scavenger receptor class D member1) (FITC)

• Catalog number
  MBS600751
• Price
  Please ask
• Size
  100 Tests

• Products_type
  Antibody
• Products_short_name
  [CD68CD68]
• Products_name_syn
  [CD68CD68 (MACROSIALIN, DKFZp686M18236, Macrophage antigen, SCARD1, Scavenger receptor class D member1) (FITC)]
• Other_names
  [CD68 antigen]
• Clonality
  Monoclonal
• Clone
  [6A323]
• Reactivity
  Human
• Specificity
  Recognizes the 110KD integral membrane glycoprotein CD68 (Macrosialin) predominantly expressed on the intracellular lysosomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukaemia studies.
• Purity
  Purified by Protein A affinity chromatography.
• Form
  Affinity Purified Supplied as a liquid in PBS, pH 7.4, 1% BSA, 1% sodium azide.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  Flow Cytometry
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antigens are peptides or recombinant or native dependent on the production method. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  This MyBioSource Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. MyBioSource FITC is highly sensitive to pH extremes.
• Conjugation
  Anti-FITC Antibody

• Gene target
  CD68CD68   MACROSIALIN   DKFZp686M18236   Macrophage   SCARD1   Scavenger   receptor   class   member1  
• Gene symbol
  CD68
• Short name
  Anti - CD68CD68 (MACROSIALIN, DKFZp686M18236, Macrophage antigen, SCARD1, Scavenger receptor class D member1) (FITC)
• Technique
  antigen, anti, FITC, antibody to, antigenes, Fluorescein
• Host
  Host: Mouse Source: Human
• Isotype
  IgG1
• Label
  FITC
• Alternative name
  antibody to - CD68CD68 (MACROSIALIN, DKFZp686M18236, Macrophage protein, SCARD1, Scavenger receptor class D member1) (fluorecein)
• Alternative technique
  antigenes, antibodies, fluorescine

Gene info

• Identity
  HGNC:1693
• Gene
  CD68
• Long gene name
  CD68 molecule
• Synonyms gene name
  • CD68 antigen
• Synonyms
  • SCARD1
  • macrosialin
  • GP110
  • DKFZp686M18236
  • LAMP4
• Synonyms name
  • scavenger receptor class D, member 1
  • CD68 antigen
  • macrophage antigen CD68
• GenBank acession
  • S57235
• Locus
  17p13.1
• Discovery year
  1993-06-11
• Entrez gene record
  968
• Pubmed identfication
  • 9790779
• RefSeq identity
  • NM_001251
• Classification
  • Scavenger receptors
  • Lysosome associated membrane proteins
  • CD molecules
• VEGA ID
  OTTHUMG00000108146

MeSH Data

• Name
  Fluorescent Antibody Technique
• Concept
  Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
• Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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