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CCL23 Ck beta 8 1 human recombinant

CCL23 Ck beta 8 1 human recombinant is available 0 time from Biovision labs

Target CCL-23
Background Human Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1, CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CCL23 (aa 22 -120).Additional N-terminal Processing of the 99 aa residue variant can generate a 75 aa residue peptide (aa 46-120) that is significantly more active than the 99 aa residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes, dendritic cells, and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells, but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.
Concentration N/A
Molecular weight ~11.5 kDa
Synonym G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein
Other name C-C motif chemokine 23, CK-beta-8, CKB-8, Macrophage inflammatory protein 3, MIP-3, Myeloid progenitor inhibitory factor 1, MPIF-1, Small-inducible cytokine A23, CCL23 (19-99), CCL23 (22-99), CCL23 (27-99), CCL23 (30-99)
NCBI gene number 6348
NCBI gene CCL3
Gene source Human
NCBI number P10147
Recombinant Yes
Source E. coli
Purification ≥95%
Tested applications SDS-PAGE, HPLC
Tested activity N/A
Biological activity The ED50 of rhCCL23 was 0.2-0.5 μg/mL as determined by its ability to chemoattract THP1 human acute monocytic leukemia cells. The ED50 of rhCCL23 was 0.02-0.1 μg/mL as determined by its ability to chemoattract human CCR1 transfected BaF3 mouse proB cells.
Reesults 0.2-0.5 μg/ml
Binding ability N/A
Unit N/A
Storage condition -20°C
Shipping under Gel pack
Physical appearance Lyophilized protein
Physical properties Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2.
How to reconstitute Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/ml.). This can further be diluted to other aqueous buffers.
Aa sequence Recombinant Human CCL23 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 100 amino acids with an extra N-terminal Met and having a molecular mass of 11.5 kDa. The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Val-Thr-Lys.
Before use Centrifuge the vial prior to opening.
Notes For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetCCL23/Ck beta 8-1
Short name CCL23/Ck beta 8-1, recombinant
Technique Recombinant
Species Human
Alternative name CCL23/Ck b 8-1, H. sapiens recombinant
Alternative technique rec
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CCL23 Ck beta 8 1 human recombinant -
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • CCL23/Ck
  • beta
  • 8-1
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