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Alternative_name
4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide; PRT2070; PRT-2070; PRT 2070; PRT-062070; PRT 062070; PRT062070.
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Description
Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. It preferentially inhibits JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 is inhibited with an IC₅₀ of 0.27 μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, are inhibited with IC₅₀’s within the range of 0.11 μM to 0.57 μM.
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CAS Number
1198300-79-6
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₂₀H₂₇N₇O₃S
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Molecular Weight
445.54
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Cell Permeable
Y
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Purity
≥98% by HPLC
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Solubilities
DMSO (>40 mg/ml)
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Handling
Protect from light and moisture
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Tag Line
A novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor
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Storage Condition
-20°C
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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PubChem CID
44595079
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SMILES
CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N
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InChi
nChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25)
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InChi Key
BGLPECHZZQDNCD-UHFFFAOYSA-N
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MSDS Available
Yes
