I-BET151

• Catalog number
  2220-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  GSK1210151A
• Description
  A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action is, at least in part, due to suppressing the transcription of key genes (BCL2, C-MYC and CDK6) that are critical for MLL-fusion leukemia maintenance.
• CAS Number
  1300031-49-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₁N₅O₃
• Molecular Weight
  415.44
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC (≥99.5% optical purity)
• Solubilities
  DMSO (100 mM) or Ethanol (100 mM)
• Handling
  Protect from light and moisture
• Tag Line
  A BET bromodomain inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD22124472
• PubChem CID
  52912189
• PubChem CID Link
• SMILES
  CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC
• InChi
  InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
• InChi Key
  VUVUVNZRUGEAHB-CYBMUJFWSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  I-BET151  
• Gene symbol
  FABP6, TANK, FABP2, PSMB2, CPLX1, MDFI, B3GAT3, IGLVI-38, XYLT1
• Short name
  I-BET151
• Alternative name
  I-BET151

Gene info

• Identity
  HGNC:3561
• Gene
  FABP6
• Long gene name
  fatty acid binding protein 6
• Synonyms gene name
  • fatty acid binding protein 6, ileal
• Synonyms
  • I-15P
  • ILLBP
  • I-BAP
  • ILBP3
  • I-BABP
  • ILBP
  • I-BALB
• Synonyms name
  • illeal lipid-binding protein
  • ileal bile acid binding protein
  • gastrotropin
• GenBank acession
  • U19869
• Locus
  5q33.3
• Discovery year
  1997-09-12
• Entrez gene record
  2172
• Pubmed identfication
  • 7894165
  • 7619861
• RefSeq identity
  • NM_001040442
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130329

Gene info

• Identity
  HGNC:11562
• Gene
  TANK
• Long gene name
  TRAF family member associated NFKB activator
• Synonyms gene
  • TRAF2
• Synonyms gene name
  • TRAF family member-associated NFKB activator
• Synonyms
  • I-TRAF
• GenBank acession
  • U59863
• Locus
  2q24.2
• Discovery year
  1997-06-12
• Entrez gene record
  10010
• Pubmed identfication
  • 8710854
  • 8855313
• RefSeq identity
  • NM_133484
• VEGA ID
  OTTHUMG00000132037

Gene info

• Identity
  HGNC:3556
• Gene
  FABP2
• Long gene name
  fatty acid binding protein 2
• Synonyms gene name
  • fatty acid binding protein 2, intestinal
• Synonyms
  • I-FABP
• GenBank acession
  • J03465
• Locus
  4q26
• Discovery year
  1986-01-01
• Entrez gene record
  2169
• RefSeq identity
  • NM_000134
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000132972

Gene info

• Identity
  HGNC:9539
• Gene
  PSMB2
• Long gene name
  proteasome 20S subunit beta 2
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 2
  • proteasome subunit beta 2
• Synonyms
  • HC7-I
• Synonyms name
  • proteasome subunit β4
• GenBank acession
  • D26599
• Locus
  1p34.3
• Discovery year
  1995-05-03
• Entrez gene record
  5690
• Pubmed identfication
  • 7918633
• RefSeq identity
  • NM_002794
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000004169

Gene info

• Identity
  HGNC:2309
• Gene
  CPLX1
• Long gene name
  complexin 1
• Synonyms
  • CPX-I
• GenBank acession
  • AF022383
• Locus
  4p16.3
• Discovery year
  1999-09-09
• Entrez gene record
  10815
• Pubmed identfication
  • 7553862
• VEGA ID
  OTTHUMG00000160005

Gene info

• Identity
  HGNC:6967
• Gene
  MDFI
• Long gene name
  MyoD family inhibitor
• Synonyms
  • I-mfa
• Synonyms name
  • inhibitor of MyoD family a
• GenBank acession
  • U78313
• Locus
  6p21.1
• Discovery year
  1997-10-17
• Entrez gene record
  4188
• Pubmed identfication
  • 9250874
  • 17289077
• RefSeq identity
  • NM_005586
• VEGA ID
  OTTHUMG00000014681

Gene info

• Identity
  HGNC:923
• Gene
  B3GAT3
• Long gene name
  beta-1,3-glucuronyltransferase 3
• Synonyms gene name
  • beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
• Synonyms
  • GlcAT-I
• Synonyms name
  • glucuronosyltransferase I
  • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
• GenBank acession
  • AB009598
• Locus
  11q12.3
• Discovery year
  2000-01-07
• Entrez gene record
  26229
• Pubmed identfication
  • 9506957
• RefSeq identity
  • NM_012200
• Classification
  • Beta-1,3-glucuronyltransferases
• VEGA ID
  OTTHUMG00000167685

Gene info

• Identity
  HGNC:5935
• Gene
  IGLVI-38
• Long gene name
  immunoglobulin lambda variable (I)-38 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-38
  • immunoglobulin lambda variable (I)-38 pseudogene
• Synonyms
  • IGLV(I)-38
• GenBank acession
  • D87009
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28768
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151073

Gene info

• Identity
  HGNC:15516
• Gene
  XYLT1
• Long gene name
  xylosyltransferase 1
• Synonyms gene name
  • xylosyltransferase I
• Synonyms
  • XT-I
  • PXYLT1
• Synonyms name
  • protein xylosyltransferase 1
• GenBank acession
  • AJ277441
• Locus
  16p12.3
• Discovery year
  2001-04-06
• Entrez gene record
  64131
• Pubmed identfication
  • 11099377
  • 23982343
• RefSeq identity
  • NM_022166
• Classification
  • Glucosaminyl (N-acetyl) transferases/xylosyltransferases
• VEGA ID
  OTTHUMG00000129975

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