CD437

• Catalog number
  2636-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  6-​(4-​hydroxy-​3-​tricyclo[3.3.1.13,​7]dec-​1-​ylphenyl)-​2-​naphthalenecarboxylic acid; AHPN
• Description
  CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.
• CAS Number
  125316-60-1
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₆O₃
• Molecular Weight
  398.49
• Cell Permeable
  Yes
• Purity
  >95%
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective RARgamma agonist and stem cell fate modulator
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD3106506
• PubChem CID
  135411
• PubChem CID Link
• SMILES
  C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O
• InChi
  InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
• InChi Key
  LDGIHZJOIQSHPB-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CD437  
• Short name
  CD437
• Alternative name
  CD437

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