FK-866

• Catalog number
  1914-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
• Description
  Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC₅₀ = ~1 nM).
• CAS Number
  658084-64-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₉N₃O₂
• Molecular Weight
  391.51
• Cell Permeable
  Yes
• Purity
  ≥98% by NMR
• Solubilities
  DMSO (>30 mg/ml) and Ethanol
• Handling
  Protect from light and air
• Tag Line
  A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  6914657
• PubChem CID Link
• SMILES
  C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
• InChi
  InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13- 17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14, 16-18H2,(H,26,28)/b12-11+
• InChi Key
  KPBNHDGDUADAGP-VAWYXSNFSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  FK-866  
• Short name
  FK-866
• Alternative name
  FK-866

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