SNS-032

• Catalog number
  9490-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide; BMS-387032
• Description
  SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀ >1000 nM). Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
• CAS Number
  345627-80-7
• Structure Available
  Yes
• Molecular Formula
  C₁₇H₂₄N₄O₂S₂
• Molecular Weight
  380.53
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent CDK (cyclin-dependent kinase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  3025986
• PubChem CID Link
• SMILES
  CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
• InChi
  InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
• InChi Key
  OUSFTKFNBAZUKL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SNS-032  
• Gene symbol
  SCN10A, SCN11A
• Short name
  SNS-032
• Alternative name
  SNS-032

Gene info

• Identity
  HGNC:10582
• Gene
  SCN10A
• Long gene name
  sodium voltage-gated channel alpha subunit 10
• Synonyms gene name
  • sodium channel, voltage-gated, type X, alpha polypeptide
  • sodium channel, voltage-gated, type X, alpha subunit
  • sodium channel, voltage gated, type X alpha subunit
• Synonyms
  • Nav1.8
  • hPN3
  • SNS
  • PN3
• Synonyms name
  • sensory neuron sodium channel
  • peripheral nerve sodium channel 3
• GenBank acession
  • AF117907
• Locus
  3p22.2
• Discovery year
  1996-04-12
• Entrez gene record
  6336
• Pubmed identfication
  • 9839820
  • 10198179
  • 16382098
• RefSeq identity
  • NM_006514
• Classification
  • Sodium voltage-gated channel alpha subunits
• VEGA ID
  OTTHUMG00000048245

Gene info

• Identity
  HGNC:10583
• Gene
  SCN11A
• Long gene name
  sodium voltage-gated channel alpha subunit 11
• Synonyms gene
  • SCN12A
• Synonyms gene name
  • sodium channel, voltage-gated, type XI, alpha polypeptide
  • sodium channel, voltage-gated, type XII, alpha
  • sodium channel, voltage-gated, type XI, alpha subunit
  • sodium channel, voltage gated, type XI alpha subunit
• Synonyms
  • Nav1.9
  • NaN
  • SNS-2
• GenBank acession
  • AF126739
• Locus
  3p22.2
• Discovery year
  1998-11-06
• Entrez gene record
  11280
• Pubmed identfication
  • 10444332
  • 16382098
• RefSeq identity
  • NM_014139
• Classification
  • Sodium voltage-gated channel alpha subunits
• VEGA ID
  OTTHUMG00000048246

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