Human CellExp™ DLL4, Mouse Recombinant

• Catalog number
  P1163-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  Delta-like Protein 4, Delta 4
• Alternative_names
  Delta-like Protein 4, Delta 4
• Description
  Activates the Notch-1 and Notch-2 receptors
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  > 90%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per/ug
• Activity Specifications test method
  Measured by inhibition of adipogenesis of 3T3L-1 cells
• Biological activity
  Inhibits adipogenesis of 3T3L-1 cells
• Molecular Weight
  95 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Liquid
• Physical form description
  0.2 um-filtered solution in PBS
• Background Information
  The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   DLL4  
• Gene symbol
  DLL4
• Short name
  CellExp™ DLL4, Mouse Recombinant
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Humans, Mouses
• Alternative name
  H. sapiens CellExp™ DLL4, Mouse Rec.
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:2910
• Gene
  DLL4
• Long gene name
  delta like canonical Notch ligand 4
• Synonyms gene name
  • delta-like 4 homolog (Drosophila)
  • delta-like 4 (Drosophila)
• GenBank acession
  • AF253468
• Locus
  15q15.1
• Discovery year
  2000-07-31
• Entrez gene record
  54567
• Pubmed identfication
  • 10837024
• VEGA ID
  OTTHUMG00000172511
• Locus Specific Databases
  • LRG_1268

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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