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Also known as
ANGIOGENIN
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Other names
angiogenin; Angiogenin; angiogenin; RNase 5; ribonuclease 5; epididymis luminal protein 168; angiogenin, ribonuclease, RNase A family, 5; Ribonuclease 5
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
ANG; ANG; ALS9; HEL168; RNASE4; RNASE5; RNASE5; RNase 5
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Gene name synonims
ANG; ANG; ALS9; HEL168; RNASE4; RNASE5; RNASE5; RNase 5
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Other gene names
ANG; ANG; ALS9; HEL168; RNASE4; RNASE5; RNASE5; RNase 5
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Clonality
Monoclonal
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Immunoglobulin isotype
IgM
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Clone
MANG-1
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Host organism
Mouse (Mus musculus)
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Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
ANGIOGENIN Mouse anti Human Angiogenin (MANG-1) is a monoclonal antibody specific for angiogenin, a potent angiogenesis inducing polypeptide of approximately 16.5kDa responsible for inducing vascularization in both normal and malignant tissues through activation of vascular endothelium and smooth muscle cells ant triggering a number of processes including Cell migration and proliferation (Reviewed in) Angiogenin, also known as ribonuclease 5 demonstrates tRNA specific ribonuclease activity, this in turn is regulated by binding to the ribonuclease inhibitor. Angiogenin exerts its vascular stimulation potential through binding to cytoplasmic actin on the surface of endothelial cells, followed by endocytosis and subsequent translocation to the nucleus Mouse anti Angiogenin, clone MANG1 stains single cells on human tonsil sections and endothelial cells in human terminal placenta. MANG-1 also demonstrates intense staining on carcinoma cells and of endothelial cells in intratumoral vessels; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
N/A
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Form Appearance
S/N (Tissue Culture Supernatant - lyophilised)
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Concentration
IgG concentration 0.3 mg/ml
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Storage and shipping
Prior to reconstitution Keep the antibody refrigerated at +4 degrees Celsius. Temperature variations in the range between +1C to +7C are tolerable. After reconstitution Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. Shelf Life: 12 months from date of reconstitution.
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Tested applications
ELISA (EIA), Immunohistology - Frozen (IHC), Immunohistology - Paraffin (IHC)
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Test
MBS Monoclonals supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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French translation
anticorps
