Tariquidar

Alternative_name

N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide; XR9576, XR 9576, XR-9576,Tariquidar
Description

Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein (P-gp) (Kd = 5.1 nM). Tariquidar inhibits the ATPase activity of P-gp, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both. At low concentrations, Tariquidar acts selectively as an inhibitor of P-gp and as a substrate of BCRP (breast cancer resistance protein). At much higher concentrations (≥100 nM). Tariquidar acts as an inhibitor of both P-gp and BCRP.
CAS Number

206873-63-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₈H₃₈N₄O₆
Molecular Weight

646.73
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>6 mg/ml)
Handling

Protect from air and light
Tag Line

A P-glycoprotein (P-gp) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

148201
PubChem CID Link
SMILES

COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC
InChi

InChI=1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43)
InChi Key

LGGHDPFKSSRQNS-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes