Telaprevir

Alternative_name

(3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Description

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease. Telaprevir inhibits the hepatitis C virus NS3-4A serine protease, blocking the viral polyprotein processing. The dose dependent process leads to decrease in viral RNA replication, decreased HCV RNA and protein levels in con1 subgenomic HCV replicon cells.
CAS Number

402957-28-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₆H₅₃N₇O₆
Molecular Weight

679.85
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO(>100 mg/ml)
Handling

Protect from air and light
Tag Line

A hepatitis C virus protease inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD11616089
PubChem CID

3010818
PubChem CID Link
SMILES

CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3CCCC3CN2C(=O)C(C(C)(C)C)NC(=O)C(C4CCCCC4)NC(=O)C5=NC=CN=C5
InChi

InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1
InChi Key

BBAWEDCPNXPBQM-GDEBMMAJSA-N
Data Sheet Link
MSDS Available

Yes