NVP-BSK805 dihydrochloride
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Catalog number
B2200-5
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Price
Please ask
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Size
5 mg
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Alternative_name
4-(2,6-difluoro-4-(3-(1-(pip4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine, dihydrochloride
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Description
NVP-BSK805 is a potent and selective ATP-competitive inhibitor of JAK2 (IC₅₀ = 0.5 nM,). It displays >20-fold selectivity towards JAK1, JAK3 and TYK2.
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CAS Number
1942919-79-0
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₇H₂₈F₂N₆O • 2HCl
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Molecular Weight
563.5
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~ 20 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent and selective ATP-competitive JAK2 inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
57339395
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SMILES
C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
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InChi
InChI=1S/C27H28F2N6O.2ClH/c28-23-12-18(13-24(29)22(23)17-34-8-10-36-11-9-34)21-2-1-3-25-27(21)33-26(15-31-25)19-14-32-35(16-19)20-4-6-30-7-5-20;;/h1-3,12-16,20,30H,4-11,17H2;2*1H
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InChi Key
NUOCAPALWRHKCU-UHFFFAOYSA-N
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MSDS Available
Yes
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