(R)-Tiagabine 4-Carboxy-O-ethyl Hydrochloride

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Cas number

145821-60-9
Chemical s molecular weight

440.06
Chemical s main applications

(R)-Tiagabine 4-Carboxy-O-ethyl Hydrochloride is a derivative of N-diarylalkenylpiperidinecarboxylic Acid and a γ-aminobutyric acid uptake inhibitor. Derivative of Tiagabine Hydrochloride (T436400), A GABA uptake inhibitor. Anticonvulsant.
Chemical s category

Heterocycles, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Other name

(R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic Acid Ethyl Ester, Hydrochloride; Ethyl Tiagabinate Hydrochloride; USP Tiagabine Hydrochloride Related Compound A;
Chemical s formula

C22H30ClNO2S2
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications

Gene target

Tiagabine 4-Carboxy-O-ethyl Hydrochloride
Gene symbol

CENPO, H4C15, POFUT1, SDR9C7, GNAO1, H3C15, H2BC19P, FABP3, OGT, AOPEP
Short name

(R)-Tiagabine 4-Carboxy-O-ethyl Hydrochloride
Alternative name

(R)-Tiagabine 4-Carboxy-O-ethyl Hydrochloride

Identity

HGNC:29607
Gene

H4C15
Long gene name

H4 clustered histone 15
Synonyms gene
- HIST2H4B
Synonyms gene name
- histone 2, H4b
- histone cluster 2, H4b
- histone cluster 2 H4 family member b
Synonyms
- H4/o
GenBank acession
- BC108260
Locus

1q21.2
Discovery year

2006-06-12
Entrez gene record

554313
Pubmed identfication
- 15527963
RefSeq identity
- NM_001034077
Classification
- H4 histones
VEGA ID

OTTHUMG00000188201

Identity

HGNC:14988
Gene

POFUT1
Long gene name

protein O-fucosyltransferase 1
Synonyms
- O-FUT
- O-Fuc-T
- KIAA0180
- FUT12
Synonyms name
- peptide-O-fucosyltransferase
- GDP-fucose protein O-fucosyltransferase 1
GenBank acession
- AF375884
Locus

20q11.21
Discovery year

2001-10-29
Entrez gene record

23509
Pubmed identfication
- 9023546
- 9525914
RefSeq identity
- NM_015352
Classification
- MicroRNA protein coding host genes
- Fucosyltransferases
VEGA ID

OTTHUMG00000133268

Identity

HGNC:4389
Gene

GNAO1
Long gene name

G protein subunit alpha o1
Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms
- G-ALPHA-o
Locus

16q13
Discovery year

1988-04-24
Entrez gene record

2775
Pubmed identfication
- 1899283
- 11395521
RefSeq identity
- NM_020988
Classification
- G protein subunits alpha, group i
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000133241

Identity

HGNC:20505
Gene

H3C15
Long gene name

H3 clustered histone 15
Synonyms gene
- HIST2H3A
Synonyms gene name
- histone 2, H3a
- histone cluster 2, H3a
- histone cluster 2 H3 family member a
Synonyms
- H3/n
- H3/o
GenBank acession
- AF531305
Locus

1q21.2
Discovery year

2003-02-19
Entrez gene record

333932
Pubmed identfication
- 12408966
- 15527963
Classification
- H3 histones
VEGA ID

OTTHUMG00000012094

Identity

HGNC:20517
Gene

H2BC19P
Long gene name

H2B clustered histone 19, pseudogene
Synonyms gene
- H2BFO
- HIST2H2BD
Synonyms gene name
- histone 2, H2bd
- H2B histone family, member O
- histone cluster 2, H2bd (pseudogene)
- histone cluster 2 H2B family member d (pseudogene)
Synonyms
- H2B/s
- H2B/o
GenBank acession
- AY131978
Locus

1q21.2
Discovery year

2003-02-20
Entrez gene record

337874
Pubmed identfication
- 12408966
- 15527963
RefSeq identity
- NG_001226
Classification
- H2B histones
VEGA ID

OTTHUMG00000035827

Identity

HGNC:3557
Gene

FABP3
Long gene name

fatty acid binding protein 3
Synonyms gene
- MDGI
- FABP11
Synonyms gene name
- fatty acid binding protein 11
- fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
- fatty acid binding protein 3, muscle and heart
Synonyms
- H-FABP
- O-FABP
Synonyms name
- mammary-derived growth inhibitor
GenBank acession
- U57623
Locus

1p35.2
Discovery year

1991-08-06
Entrez gene record

2170
Pubmed identfication
- 8661024
RefSeq identity
- NM_004102
Classification
- Fatty acid binding protein family
VEGA ID

OTTHUMG00000003797

Identity

HGNC:8127
Gene

OGT
Long gene name

O-linked N-acetylglucosamine (GlcNAc) transferase
Synonyms gene name
- O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Synonyms
- O-GLCNAC
- HRNT1
- MGC22921
- FLJ23071
- OGT1
Synonyms name
- UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
GenBank acession
- U77413
Locus

Xq13.1
Discovery year

1998-12-03
Entrez gene record

8473
Pubmed identfication
- 9083068
RefSeq identity
- NM_003605
- NM_181672
Classification
- O-linked N-acetylglucosaminyltransferases
- NSL histone acetyltransferase complex
- Tetratricopeptide repeat domain containing
VEGA ID

OTTHUMG00000033316
Locus Specific Databases
- Global Variome shared LOVD