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Synonyms
COX-2, Prostaglandin G/H synthase 2 (PGHS-2)
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Alternative_names
COX-2, Prostaglandin G/H synthase 2 (PGHS-2)
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Description
Catalyzes the conversion of arachidonic acid to prostaglandin H2
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Recombinant
Yes
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Source
E.coli
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Activity Specifications test method
Measured by its ability to generates 1.0 µmol of hydrogen peroxide from arachidonic acid per minute at pH 8.0, 25°C.
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Biological activity
Specific activity is ≥100 mU/mg
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Results
≥100 mU/mg
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Molecular Weight
68 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized in proprietary buffer
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Reconstitution Instructions
Reconstitute in deionized water to final concentration of 1 µg/µl
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Background Information
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. COX consists of two isoforms, COX-1 and COX-2. The COX enzymes, membrane-associated heme proteins that have cyclooxygenase and peroxidase activities, are targets of NSAID (non-steroidal anti-inflammatory drugs). COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Insects (from Latin insect, a calque of Greek ἔντομον [éntomon], "cut into sections") are a class of invertebrates within the arthropod phylum that have a chitinous exoskeleton, a three-part body (head, thorax and abdomen), three pairs of jointed legs, compound eyes and one pair of antennae. They are the most diverse group of animals on the planet, including more than a million described species and representing more than half of all known living organisms. The number of extant species is estimated at between six and ten million, and potentially represent over 90% of the differing animal life forms on Earth. Insects may be found in nearly all environments, although only a small number of species reside in the oceans, a habitat dominated by another arthropod group, crustaceans. There are non competitive and competitive antagonists.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
