Motesanib

• Catalog number
  2022-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  AMG-706
• Description
  Cell-permeable. Motesanib, also known as AMG-706, is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC₅₀ values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).  It also potently inhibits angiogenesis and induces regression in tumor xenografts.
• CAS Number
  453562-69-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₂₃N₅O
• Molecular Weight
  373.45
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (200 mg/ml) or EtOH (40 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent multikinase inhibitor selective to VEGFRs and PDGFrs
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD10567689
• PubChem CID
  11667893
• PubChem CID Link
• SMILES
  CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
• InChi
  InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3- 9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H, 27,28)
• InChi Key
  RAHBGWKEPAQNFF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Motesanib  
• Short name
  Motesanib
• Alternative name
  Motesanib

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