Thiocolchicine
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Catalog number2213-5
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PricePlease ask
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Size5 mg
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Alternative_name10-Demethoxy-10-methylthiocolchicine; NSC 186301
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DescriptionAn antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.
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CAS Number2730-71-4
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₂H₂₅NO₅S
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Molecular Weight415.5
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Cell PermeableYes
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Purity³95% by NMR
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA tubulin polymerization and microtubule assembly inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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PubChem CID546854
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SMILESCC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
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InChiInChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
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InChi KeyCMEGANPVAXDBPL-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameThiocolchicine
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Alternative nameThiocolchicine
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